ea0070oc5.1 | Thyroid | ECE2020
Alikhani Pouya
, Gonzalez-Guerrero Cristian
, Liao Xiao-Hui
, Borsò Marco
, Peluso Teresa
, Zucchi Riccardo
, Refetoff Samuel
, Moreno Jose Carlos
Background: Most thyroid specific genes are transcriptionally regulated by TSH-TSHR signalling and T4-driven negative feedback of TSH secretion at the pituitary. However, local autoregulation of transcription has been described from IGF-IGFR, follicular thyroglobulin, or iodine. We aimed to investigate the TSH dependency of thyroid transcriptional regulation in the Dehal1 knockout, devoid of iodide-recycling capacity from iodotyrosines.Methods: ...